This table lists the beta-1 blockade potency ratios for beta-adrenergic receptor blockers. These ratios are compared to propranolol, which has a ratio of 1.
|
Beta-Blockers |
Potency Ratio Propranolol = 1 |
Generation |
|---|---|---|
|
Acebutolol |
0.3 |
Second |
|
Atenolol |
1.0 |
Second |
|
Bisoprolol |
10.0 |
Second |
|
Carvedilol |
10.0 |
Third |
|
Labetalol |
0.3 |
Third |
|
Metoprolol |
1.0 |
Second |
|
Nadolol |
1.0 |
First |
|
Nebivolol |
10.0 |
Third |
|
Oxprenolol |
0.5-1.0 |
First |
|
Pindolol |
6.0 |
First |
|
Propranolol |
1.0 |
First |
|
Sotalol |
0.3 |
First |
Note. Ratio data presented in the table is from:
1. Frishman WH. Alpha- and beta-adrenergic blocking drugs. In: Frishman WH, Sica DA, editors. Cardiovascular Pharmacotherapeutics. 3rd ed. Minneapolis, MN: Cardiotext Publishing; 2011:65.
2. Lechat Lechat P. Clinical pharmacology of beta-blockers in cardiology: Trial results and clinical applications. Hot topics in Cardiology. 2008;10(1):7-44.
